Vitamin D for Fertility and Pregnancy: Are you Getting Enough?

May 17

Vitamin D Fertility Pregnancy Infertility Are you curious about Vitamin D for fertility? If you’re thinking about having a baby, it’s strongly recommended that you check your Vitamin D level, especially if you’ve been trying for a while or have a history of pregnancy loss.  Your doctor can order a simple blood test to ensure you have enough of this vitamin that is so important for fertility and healthy pregnancies – for both mothers and their children.  Vitamin D is typically low in the winter and spring months and in darker northern climates.  A Vitamin D deficiency puts pregnant women at risk of developing serious health complications.

Preconception & Infertility

If you’re having trouble conceiving, low Vitamin D could contribute to your fertility issues.  A low level has been associated with Repeated Pregnancy Loss and Unexplained Infertility.  It’s been found to affect implantation, which can cause biochemical pregnancies or miscarriages. [i]. Also, more research is being done on PCOS (Polycystic Ovarian Syndrome) since these women often have Vitamin D deficiency, and evidence is showing that supplementation may be beneficial for egg development and regulating menstruation. [iii]. One study found a healthier increased uterine lining in women with PCOS who were given Vitamin D during their IUI cycles. [ii].

A study (published in Fertility & Sterility in 2014) of 99 women undergoing IVF (in-vitro fertilization) at USC in Southern California looked at the impact of Vitamin D on IVF cycles. The percentage of women who became pregnant was 74% in those with sufficient vitamin D levels (above 30 ng/ml), 42% in women who were insufficient (20-30), and only 35% with deficiency (below 20).  Babies were born to 59% of the women with adequate D levels (above 30) and 31% of women below 30.  [iv].

Vitamin D Fertility Pregnancy

If you’re thinking about having a baby it’s strongly recommended that you have your Vitamin D level checked, especially if you’ve been trying for a while or have a history of pregnancy loss.

Vitamin D in Pregnancy

Vitamin D is essential for brain development.  A recent study of more than 8,000 women and their children in the Netherlands showed a clear correlation between Vitamin D deficiency and autism.  Children whose mothers tested low in their 20th week of pregnancy were more likely to have autistic traits by age six. [v].  Other studies have seen an increased risk of schizophrenia with inadequate Vitamin D. [vi, vii].

When a mom’s Vitamin D level is too low, deficiency can occur at birth.  Babies receive this vitamin through the placenta and after birth through breast milk or fortified formula.  Babies who are solely breastfed are more at risk of having deficient Vitamin D because human milk has a deficient concentration, about 1.5-3% of the mother’s level.  So, exposure to sunlight is also recommended. [viii].  An Irish study found their dark winters produced more babies born in March and April with Vitamin D insufficiency, about 46% of births during that time.  You can read more about the importance of Vitamin D during pregnancy and while breastfeeding here.

Low Vitamin D during pregnancy has been linked to small-for-gestational-age births, increased susceptibility to infections, and reduced bone density. [viii].  Kids whose moms did not have sufficient Vitamin D in their 3rd trimester had more broken bones than other children.  An Australian study published in 2016 tells us that children lacking D in early childhood are more prone to developing allergic disorders like asthma and eczema. [ix].

Also, it’s essential to know that pregnant women with low D are more susceptible to developing preeclampsia, a pregnancy complication including high blood pressure and kidney problems, which can have severe consequences. [x]. An earlier birth by medical induction is often necessary, increasing the odds of cesarean delivery.   Vitamin D deficiency has also been associated with developing gestational diabetes, so you want to ensure your level stays within an optimum range.

What Level is Best?

30 ng/ml or higher seems to be most protective.  In several studies, levels of 10-20 ng/ml have been linked to disease risk.  In a 2016 study of pregnant women in Ireland, a lower risk of preeclampsia and small-for-gestational-age births were seen when levels were above 30.  Also, no adverse effects were found when Vitamin D was over 50 ng/ml. [xi]. This is reassuring since many people are concerned about taking too much.  It seems it’s much more risky not to have enough.

In an English study from 2011, they reported: “of 40 mother-infant pairs, 76% of mothers and 81% of newborns had a 25(OH)D below 20 ng/ml at the time of birth, even though during pregnancy the mothers ingested about 600 IU/day of vitamin D from a prenatal supplement and consumption of two glasses of milk.”

In my practice, I’ve seen the levels of patients taking less than 5,000 IUs a day rise very slowly.  Higher doses are required to increase levels by 10 points or more. In our experience with patients, oftentimes, 2,000-3,000 IUs a day is not enough to increase serum levels.

When are you at Risk?

  • You’re more likely to have low Vitamin D if you’ve had pregnancies close together
  • Obesity, kidney or liver disease, anemia and malabsorption issues all affect D levels
  • A strict vegetarian or vegan diet (no fish) needs to be supplemented with Vitamin D
  • People with darker skin make less Vitamin D than those with lighter-skin, so they are even more likely to be deficient

Some medications like anti-fungals, anti-seizure drugs, anti-retroviral drugs and medications used to treat osteoporosis decrease D levels in the blood, but cholesterol-lowering statin drugs and diuretics used for high blood pressure increase Vitamin D.

Vitamin D Fertility PregnancyHow do we get Vitamin D – Food and Sun!

Only a few foods contain substantial amounts of D, mostly cod liver oil and oily fish like salmon, tuna, trout, sardines and herring.  Farmed fish may have less vitamin D content than wild.  Egg yolk, liver, and mushrooms contain small quantities of D.  Some foods are fortified with it – dairy, soy milk, orange juice and cereals.  The amount in most vegetables is negligible.

But, interestingly, mushrooms that have been exposed to light are one of the few foods that naturally contain higher amounts of Vitamin D.  Placing them in the sun with the gills facing up for an hour will increase their D dramatically.   Research conducted at the Beltsville Human Nutrition Research Center showed that UV-treated portobello mushrooms contained 446 IUs per 3.5 ounces, compared to 10 IUs in untreated mushrooms.

You may think you’re outdoors so much you don’t have to worry, but wearing sunscreen with an SPF of 15 or higher blocks more than 99% of Vitamin D production so you can become deficient even in the summertime.  Protecting ourselves from skin cancers is important, so it’s probably wisest to take a supplement along with some moderate sun exposure of 15-20 minutes without sunscreen either earlier or later in the day.  I even recommended this when I was practicing in Southern California where I found Vitamin D deficiency in my patients, no matter what month it was.

Vitamin D Supplementation

Vitamin D Fertility Pregnancy

If you find out you’re deficient in Vitamin D, it’s much better to take higher doses before conceiving than trying to correct it once you’ve become pregnant.

It’s a good idea to ask your doctor to check your level of this very important vitamin at least once a year.  Vitamin D is a vital part of reproduction, affecting the health of moms and babies.  If you find out you’re deficient, taking higher doses before conceiving is much better than trying to correct it once you’ve become pregnant.  At that point you wouldn’t be able to take a larger dose to bring up your level more quickly, so your baby would not be getting the Vitamin D they need.

In addition to improving fertility, Vitamin D also strengthens our immune systems, protects us from some types of cancer and helps us maintain good bone density.  It’s an easy way to support your overall health and vitality.  And, If you have any questions, we’re always here to help!

Janene Mitchell, LAc,  FABORM, Acupuncturist

Written by Janene Mitchell, LAc, FABORM – Acupuncture, Chi Nei Tsang, Aromatherapy

Janene specializes in fertility and pregnancy care but loves working with women in all stages of their lives, including menopause and healthy aging. With a background in energetic bodywork her treatments are deeply rejuvenating.  Janene has over a decade of experience using essential oils and is a certified Chi Nei Tsang practitioner.


i. Kwak-Kim, Skariah, et al. Humoral and cellular autoimmunity in women with recurrent pregnancy losses and repeated implantation failures: A possible role of vitamin D. Autoimmunity Reviews, Volume 15, Issue 10, October 2016, Pages 943–947

ii. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review, Irani, Mohamad et al. Fertility and Sterility, Volume 102, Issue 2, 460 – 468.e3

iii. M Asadi, N Matin et al, Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized double-blind placebo-controlled trial.  Archives of Gynecology and Obstetrics  Apr 2014, Volume 289, Issue 4, pp 865–870

iv. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles, Rudick, Briana J. et al. Fertility and Sterility, Volume 101, Issue 2, 447 – 452

v. Vinkhuyzen, Eyles, et al, Gestational vitamin D deficiency and autism-related traits: the Generation R Study. Molecular Psychiatry advance online publication 29 November 2017

vi. McGrath JJ, Burne TH, Féron F, Mackay-Sim A, Eyles DW,  Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull 2010; 36: 1073–1078.

vii.  DeLuca, G. C., Kimball, S. M., Kolasinski, J., Ramagopalan, S. V. and Ebers, G. C. (2013), Review: The role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol, 39: 458–484.

viii.  Mulligan, Felton, et al, Implications of vitamin D deficiency in pregnancy and lactation, Am J Obstet Gynecol. 2010 May; 202(5): 429.e1–429.e9.

ix. Vitamin D status through the first 10 years of life: A vital piece of the puzzle in asthma inception, Litonjua, Augusto A. et al. Journal of Allergy and Clinical Immunology, Volume 139, Issue 2, 459 – 461

x. Bodnar, Catov et al, Maternal Vitamin D Deficiency Increases the Risk of Preeclampsia, J Clin Endocrinol Metab (2007) 92 (9): 3517-3522.

xi. Kiely, Zhang et al, Vitamin D status is associated with uteroplacental dysfunction indicated by pre-eclampsia and small-for-gestational-age birth in a large prospective pregnancy cohort in Ireland with low vitamin D status. Am J Clin Nutr. 2016 Aug;104(2):354-61.     doi: 10.3945/ajcn.116.130419. Epub 2016 Jun 29.